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FRONTLINE ORGANIC FRESH® – ENHANCED CLEANING PROTOCOL FOR CORONAVIRUS/COVID-19 SANITATION

Enhanced Cleaning Protocol for Coronavirus / Covid-19 Sanitation

Product Information

  • FRONTLINE Organic Fresh® is a carefully formulated complex of unique flavonoids and plant extracts focused on the strengthening of the capacity of bacteria and microbes to limit and even eliminate the negative and potentially harmful outcomes of viral attacks. This is particularly well established through strengthening cell walls.

 

  • The flavonoids and other beneficial compounds in FRONTLINE Organic Fresh® have shown to stimulate bacteria specific unique restriction patterns in genes to effectively protect host bacteria and microbes through the formation of defence mechanisms, allowing bacteria to chop up potentially harmful foreign DNA (e.g., DNA from bacteria-infecting viruses)

 

  • FRONTLINE Organic Fresh® formulations can be absorbed through the skin and the mucus membranes of the body, nose, mouth and lungs, making it a very suitable carrier for the flavonoids to be absorbed in the bloodstream and as such reach the important infected areas in the respiratory channel.

 

  • The positive effects of flavonoids on the different aspects of human health have been extensively researched over a very long period.

 

  • International research-proven ingredient specific medical oral intake confirmation.

 

  • Application through mystifying sprays outside and inside.

    This focuses on different target areas:

 

  • Outside – to distribute the protective effect of FRONTLINE Organic Fresh® on surfaces and groups. Target sprays should be applied at least once per day.

 

  • Inside buildings – as air spray and to cover all exposed surfaces without incurring an accumulation effect. This will also ensure that individuals and groups inside buildings can continuously provide protective sprays of the effective flavonoids and compounds to secure protection against the destructive effects of the COVID19 in the lungs of individuals.

 

  • This will provide added health benefits to exposed individuals whilst promoting a protective and restorative respiratory experience to the individual.

The Science behind Frontline Organic Fresh®

The FRONTLINE Organic Fresh® Dermural Sanitiser  citrus extracts contain flavonoid compounds which have proven antimicrobial activity towards Staphylococcus aureusPseudomonas aeruginosa and Escherichia coli, killing 99.9% of these pathogens at dilutions of 1% after one minute contact time when tested in accordance with Section 5.2 of SANS 1615-2011.

Polyphenols display broad antimicrobial activity towards bacteria, fungi and viruses. Antibacterial activity of citrus bioflavonoids has also been shown, with increased activity towards gram-negative bacteria.

Polyphenols also possess antiviral activity toward a range of viruses including RNA viruses (norovirus surrogates, rotavirus, enteroviruses, influenza A and B viruses, respiratory syncytial virus, human immunodeficiency virus-1, hepatitis C virus, Japanese encephalitis virus, dengue virus, West Nile virus, and Zika virus) and DNA viruses (hepatitis B virus, herpes simplex virus, and varicella-zoster virus).

In relation to the current COVID-19 pandemic, the hesperidin flavinoid found in citrus extracts has very recently, in pre-print computer-generated models, shown potential as an inhibitor to the development of the SARS-CoV-2 by binding to the viral receptors.

The 3CL protease, one of the key proteases in coronaviruses (CoV), which includes the SARS-CoV, is inhibited by a range of flavonoids. More specifically, the citrus flavonoids hesperetin, apigenin, luteolin and quercetin showed noteworthy antiviral activity through 3CL protease inhibition.

Citrus flavonoids show an immuno-regulatory role to regulate the immune response and the so-called cytokine storm associated with the overreaction of the body’s immune system which increases the severity as well as complications and high fatalities of COVID-19.

ESSENTIAL OILS AND TERPENOIDS IN DERMURAL SANITISER ORIGINAL

The FRONTLINE Organic Fresh® Dermural Sanitiser   essential oils and their isolated constituents have shown noteworthy antibacterial activity toward a range of pathogens, particularly in vitro studies assessing the effects on caries-related streptococci (mainly Streptococcus mutans) and Staphylococcus aureus, together with testing done in clinical trials.

Selected terpenes have been shown to reduce viral infectivity by 100%. The mode of antiviral action of monoterpenes towards the herpes simplex virus type 1 (HSV-1) entails their direct interaction with free virus particles, thereby inactivating viral infection of HSV-1 in a dose-dependent manner before the virus particles enter host cells.

Laurus nobilis oil, containing β-ocimene, 1,8-cineole, α-pinene, and β- pinene as the main constituents, shows activity against SARS-CoV. The addition of linalool to Syzygium aromaticum (clove) oil (main constituent Eugenol) in a synergistic manner enhances its antimicrobial efficacy against bacterium Pseudomonas aeruginosa and the fungus Aspergillus brasiliensis.

Studies on linalool-containing essential oils indicate that this compound possesses antimicrobic, antibacterial and antiviral effects, as well as anti-inflammatory, analgesic and local anaesthetic activities.

Eugenol is virucidal towards HSV-1, HSV-2 and inhibits replication. The latter’s virucidal activity was found to be higher than clinical control Acyclovir alone, and in combinations was found to synergistically inhibit herpes virus replication in vitro.

Follow routine sanitizing

Guidelines: Follow routine sanitizing and disinfection procedures, using FRONTLINE Organic Fresh® to treat frequently touched and contaminated surfaces or objects for appropriate contact times as indicated on the label.

Coronavirus is not a living organism like a bacteria, but a protein molecule (RNA) covered by a protective lipid shell or encapsulation. A person becomes infected when the virus is absorbed by the victim’s mucous membranes through the eyes, nose or mouth. The Coronavirus can be picked from surfaces.

Coronavirus on surfaces normally degrades and decomposes over several days depending on the characteristics of the surface. This decomposition can be rapidly accelerated when the lipid encapsulation is degraded by the application of FRONTLINE Organic Fresh®

FRONTLINE Organic Fresh® has shown dramatic advantages over other cleaning products, in the rapid and complete breakdown of lipid structures such as fats, oils, and grease.

The lipid structure of the Coronavirus encapsulation is particularly vulnerable to rapid cleaning with FRONTLINE Organic Fresh®          

FRONTLINE Organic Fresh® also rapidly eliminates biofilms and deeply embedded organic residues and substrates that can entrap and harbor Coronavirus and other pathogens.

 

Reference and Proven Research Results

Chemistry and Biological Activities of Flavonoids: An Overview

Chemistry and Biological Activities of Flavonoids: An Overview

 

  • Flavonoids as complementary medicine for allergic diseases:

             Current evidence and future prospects.

  • Intake of flavonoids and risk of dementia
  • The Antioxidant Flavonoids, Orientin and Vicenin Enhance Repair of Radiation-Induced Damage

 

Antiviral Activity

Natural compounds are an important source for the discovery and the development of novel antiviral drugs because of their availability and expected low side effects. Naturally occurring flavonoids with antiviral activity have been recognized since the 1940s and many reports on the antiviral activity of

various flavonoids are available. Search of effective drug against human immunodeficiency virus (HIV) is the need of hour. Most of the work related with antiviral compounds revolves around inhibition of various enzymes associated with the life cycle of viruses. Structure function relationship between flavonoids and their enzyme inhibitory activity has been observed. Gerdin and Srensso demonstrated that flavan-3-o1 was more effective than flavones and flavonones in selective inhibition of HIV-1, HIV-2, and similar immunodeficiency virus infections. Baicalin, a flavonoid isolated from Scutellaria baicalensis (Lamieaceae), inhibits HIV-1 infection and replication. Baicalein and other flavonoids such as robustaflavone and hinokiflavone have also been shown to inhibit HIV-1 reverse transcriptase.

 

Another study revealed inhibition of HIV-1 entry into cells expressing CD4 and chemokine coreceptors and antagonism of HIV-1 reverse transcriptase by the flavone Oglycoside. Catechins are also known to inhibit DNA polymerases of HIV-1. Flavonoid such as demethylated gardenin A and robinetin are known to inhibit HIV-1 proteinase. It has also been reported that the flavonoids chrysin, acacetin, and apigenin prevent HIV-1 activation via a novel mechanism that probably involves inhibition of viral transcription.

 

Various combinations of flavones and flavonols have been shown to exhibit synergism. Kaempferol and luteolin show synergistic effect against herpes simplex virus (HSV). Synergism has also been reported between flavonoids and other antiviral agents. Quercetin is reported to potentiate the effects of 5- ethyl-2-dioxyuridine and acyclovir against HSV and pseudorabies infection. Studies have displayed that flavonols are more active than flavones against herpes simplex virus type 1 and the activity order was found to be galangin, kaempferol, and quercetin.

 

Zandi et al. studied the antidengue virus properties of quercetin, hesperetin, naringin, and daidzein at different stages of DENV-2 (dengue virus type-2) infection and replication cycle. Quercetin was found to be most effective against DENV-2 in Vero cells. Many flavonoids, namely, dihydroquercetin,

dihydrofisetin, leucocyanidin, pelargonidin chloride, and catechin, show activity against several types of   virus including HSV, respiratory syncytial virus, polio virus and Sindbis virus. Inhibition of viral polymerase and binding of viral nucleic acid or viral capsid proteins have been proposed as antiviral mechanisms of action.

  • Gerdin and E. Srensso, “Inhibitory effect of the flavonoid on increased

             microvascular permeability induced by various agents in rat skin,”

International Journal of Microcirculation, Clinical and Experimental, vol. 2, no.1, pp.39–46   1983.

  • P. T. Cushnie and A. J. Lamb, “Antimicrobial activity of flavonoids,”

              International Journal of Antimicrobial Agents, vol. 26, no. 5, pp. 343–356, 2005.

  • W. Critchfield, S. T. Butera, and T. M. Folks, “Inhibition of HIV activation in latently infected cells by flavonoid compounds,” AIDS Research and Human Retroviruses, vol. 12, no. 1, pp. 39–46, 1996.
  • Zandi, B. T. Teoh, S. S. Sam, P. F. Wong, M. R. Mustafa, and S. Abubakar, “Antiviral activity of four types of bioflavonoid against dengue virus type-2,” Virology Journal, vol. 8, article 560, 2011. View at:

             References

  • Grienke, U. et al. Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae. Sci. Rep. 6, 27156 (2016).
  • Pasetto, S., Pardi, V. & Mirata, R. M. Anti-HIV-1 activity of flavonoid myricetin onHIV-1 infection in a dual-chamber in vitro model. PloS One 9(12), e115323 (2014).
  • Sze, A. et al. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 9(10), E287 (2017).

Quality Control and Approvals

FRONTLINE Organic Fresh® has been subjected to very strict regulatory and quality control measures to obtain the following registrations and approvals in SA:

  • ORGANIC FRESH – Abbreviated contact safe test results – View test results
  • Safety Data Sheet – View
  • Viricidal Efficacy – View